In Marvel Zombies - A Zombicide Game: X-Men Resistance, the tables are turned as players take on the role of the X-Men, mutant Super Heroes who are trying to stop the zombie plague. This expansion introduces Hero Mode. Whereas in the core Marvel Zombies - A Zombicide Game, players are trying to spread the zombie disease, here, they take on the role of more traditional Survivors from the Zombicide franchise, fighting against the onslaught of the undead.